It was demonstrated that serum concentrations of haptoglobin (Hp), serum amyloid A and α1 acid glycoprotein were increased in a CLA experimental model in sheep. The role of the innate immune system in Cp infection has recently been investigated. Antibodies help protect against infection, but for full protection vaccine models must stimulate cellular immunity, such as the activation of CD8+ cells and IFN-γ production by Th1 cells. Current knowledge of the immunity induced by Cp indicates that resistance to infection involves both nonspecific and specific host responses. ĭespite the importance of the disease, a satisfactory vaccine model for sheep and goats has not been developed. Published data strongly indicate that human Cp infection represents an important and significant zoonosis. In addition to the direct economic losses that may occur due to leather depreciation and weight gain delay, CLA presents zoonotic potential. The BLR analysis for immunized sheep indicated an association between IgM levels and clinical progression: sheep with high IgM titers had 100.0% less risk of having CLA abscesses than animals with low IgM levels (Odds ratio = 0.000, P < 0.05).Ĭaseous lymphadenitis (CLA) is a chronic infectious disease of sheep and goats caused by the gram-positive bacteria Corynebacterium pseudotuberculosis (Cp). Both experimental groups had significantly higher IgM titers than the control group around the ninth and eleventh days PI (P < 0.05). Binary logistic regression (BLR) analysis of primarily infected sheep indicated an association between Hp concentration and CLA clinical progression: animals with high Hp values had 99.9% less risk of having CLA abscesses than animals with low Hp levels (Odds ratio = 0.001, P < 0.05). Immunized animals in Group 3 had significantly higher Hp values between the third and seventh days PI, compared with the control group (P < 0.01). Primarily infected sheep in Group 2 (inoculated with 2x10 5 Cp virulent strain) had higher Hp values between the first and ninth days post inoculation (PI) than sheep in Group 1 (control P < 0.05).
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |